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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 11% Improvement Relative Risk HCQ for COVID-19  Hall et al.  ICU PATIENTS Is very late treatment with HCQ beneficial for COVID-19? Retrospective 505 patients in the USA Lower mortality with HCQ (not stat. sig., p=0.31) c19hcq.org Hall et al., The Annals of Thoracic Su.., Feb 2022 Favors HCQ Favors control

Multi-institutional Analysis of 505 COVID-19 Patients Supported with ECMO: Predictors of Survival

Hall et al., The Annals of Thoracic Surgery, doi:10.1016/j.athoracsur.2022.01.043
Feb 2022  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now known with p < 0.00000000001 from 422 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19hcq.org
Retrospective 505 ECMO patients showing no significant difference in mortality in unadjusted results.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
risk of death, 11.2% lower, RR 0.89, p = 0.31, treatment 31 of 56 (55.4%), control 280 of 449 (62.4%), NNT 14.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hall et al., 18 Feb 2022, retrospective, USA, peer-reviewed, 15 authors.
This PaperHCQAll
Multi-institutional Analysis of 505 Patients With Coronavirus Disease-2019 Supported With Extracorporeal Membrane Oxygenation: Predictors of Survival
Celeste A Hall, MD Jeffrey P Jacobs, MSA Alfred H Stammers, James D St. Louis, J W Awori Hayanga, MD Michael S Firstenberg, CCP Linda B Mongero, PhD Eric A Tesdahl, MD Keshava Rajagopal, PhD Faisal H Cheema, CCP Kirti Patel, CCP Tom Coley, CCP Anthony K Sestokas, PhD Marvin J Slepian, MD Vinay Badhwar
The Annals of Thoracic Surgery, doi:10.1016/j.athoracsur.2022.01.043
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
References
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Bartlett, Ogino, Brodie, Initial ELSO Guidance Document: ECMO for COVID-19 Patients with Severe Cardiopulmonary Failure, ASAIO J
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Loyalka, Cheema, Rao, Rame, Rajagopal, Early Usage of Extracorporeal Membrane Oxygenation in the Absence of Invasive Mechanical Ventilation to Treat COVID-19-related Hypoxemic Respiratory Failure, ASAIO J
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Rajagopal, Keller, Akkanti, Advanced Pulmonary and Cardiac Support of COVID-19 Patients: Emerging Recommendations From ASAIO-A "Living Working Document, ASAIO J
Rajagopal, Keller, Akkanti, Advanced Pulmonary and Cardiac Support of COVID-19 Patients: Emerging Recommendations From ASAIO-a Living Working Document, Circ Heart Fail
Shih, Dimaio, Squiers, Venovenous extracorporeal membrane oxygenation for patients with refractory coronavirus disease 2019 (COVID-19): Multicenter experience of referral hospitals in a large health care system, J Thorac Cardiovasc Surg, doi:10.1016/j.jtcvs.2020.11.073
Shih, Squiers, Dimaio, Outcomes of Extracorporeal Membrane Oxygenation in Patients With Severe Acute Respiratory Distress Syndrome Caused by COVID-19 Versus Influenza, Ann Thorac Surg, doi:10.1016/j.athoracsur.2021.05.060
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Zimmermann, Bein, Arlt, Pumpless extracorporeal interventional lung assist in patients with acute respiratory distress syndrome: a prospective pilot study, Crit Care
Late treatment
is less effective
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