Implications of myocardial injury in Mexican hospitalized patients with coronavirus disease 2019 (COVID-19)

9/12 Late treatment study

Heberto et al., IJC Heart & Vasculature, doi:10.1016/j.ijcha.2020.100638 (Peer Reviewed)
Implications of myocardial injury in Mexican hospitalized patients with coronavirus disease 2019 (COVID-19)

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Observational prospective 254 hospitalized patients, HCQ+AZ mortality odds ratio OR 0.36, p = 0.04.

Ventilation OR 0.20, p = 0.008.

Heberto et al., 9/12/2020, prospective, Mexico, North America, peer-reviewed, 8 authors.

risk of death, 53.6% lower, RR 0.46, p = 0.04, treatment 139, control 115, odds ratio converted to relative risk.

risk of mechanical ventilation, 65.6% lower, RR 0.34, p = 0.008, odds ratio converted to relative risk.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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