Observational prospective 254 hospitalized patients, HCQ+AZ mortality odds ratio OR 0.36,
p = 0.04.
Ventilation OR 0.20,
p = 0.008.
Heberto et al., 9/12/2020, prospective, Mexico, North America, peer-reviewed, 8 authors.
risk of death, 53.6% lower, RR 0.46, p = 0.04, treatment 139, control 115, odds ratio converted to relative risk.
risk of ventilation, 65.6% lower, RR 0.34, p = 0.008, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious
outcomes. For an individual study the most serious outcome may have a smaller
number of events and lower statistical signficance, however this provides the
strongest evidence for the most serious outcomes when combining the results of
many trials.