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HCQ study #257 of 320   Meta Analysis
2/5 Late treatment study
Hernandez-Cardenas et al., medRxiv, doi:10.1101/2021.02.01.21250371 (Preprint)
Hydroxychloroquine for the treatment of severe respiratory infection by COVID-19: a randomized controlled trial
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Very late stage RCT with 214 patients, mean SpO2 65%, 162 on mechanical ventilation, showing no signficant difference in mortality.
Patients not intubated at baseline show greater improvement, HR 0.43 [0.09-2.03].
Table 4 shows different results to the abstract - table 4 adjusted HR 0.80 [0.51-1.23], abstract HR 0.88 [0.51-1.53]. There was no significant difference in severe adverse events.

Hernandez-Cardenas et al., 2/5/2021, Randomized Controlled Trial, Mexico, North America, preprint, 6 authors.
risk of death, 12.0% lower, RR 0.88, p = 0.66, treatment 106, control 108.
risk of death, 57.0% lower, RR 0.43, p = 0.29, subgroup not intubated at baseline.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
All 320 studies   Meta Analysis
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