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Meta-analysis of randomized trials of ivermectin to treat SARS-CoV-2 infection

Hill et al., Research Square, doi:10.21203/rs.3.rs-148845/v1

Jan 2021

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Ivermectin for COVID-19

4th treatment shown to reduce risk in August 2020

^*, now known with p < 0.00000000001 from 102 studies, recognized in 22 countries.

Lower risk for mortality, ventilation, ICU admission, hospitalization, recovery, cases, and viral clearance.

No treatment is 100% effective. Protocols combine complementary and synergistic treatments. ^* >10% efficacy in meta analysis with ≥3 clinical studies.

4,000+ studies for 60+ treatments. c19ivm.org

Meta analysis of 18 ivermectin RCTs with 2,282 patients showing faster viral clearance (dose and duration dependent), improved clinical recovery, and lower hospitalization and mortality. In six RCTs of moderate or severe infection, there was a 75% reduction in mortality, RR 0.25 [0.12-0.52], p = 0.0002.

A documentary about the external influences changing the conclusions of this study, and the resulting negative impacts, can be found at drtesslawrie.substack.com.

A sponsor reportedly required the conclusion of this paper to be changed against the wishes of the authors (to suggest that more trials should be done as opposed to the existing evidence being sufficient) francesoir.fr, reddit.com, youtube.com. Reportedly, Unitaid had influence over the conclusions trialsitenews.com, worldcouncilforhealth.org. See also roundingtheearth.substack.com.

Note that one of the 18 studies in this analysis has since been withdrawn (Elgazzar).

7 meta analyses show significant improvements with ivermectin for mortality Bryant, Hariyanto, Kory, Lawrie, Nardelli, Zein, hospitalization Schwartz, recovery Kory, and cases Kory.

Currently there are 102 ivermectin for COVID-19 studies, showing 49% lower mortality [35‑60%], 29% lower ventilation [12‑42%], 35% lower ICU admission [7‑54%], 34% lower hospitalization [20‑45%], and 81% fewer cases [71‑87%].

1. Bryant et al., Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines, American Journal of Therapeutics, doi:10.1097/MJT.0000000000001402.lww.com, doi.org.

2. drtesslawrie.substack.com, drtesslawrie.substack.com/p/a-letter-to-dr-andrew-hill.drtesslawrie.substack.com/p/a-letter-to-dr-andrew-hill.

3. francesoir.fr, www.francesoir.fr/videos-les-debriefings/le-scandale-de-livermectine-tess-lawrie-le-retour.www.francesoir.fr/videos-les-debriefings/le-scandale-de-livermectine-tess-lawrie-le-retour.

4. Hariyanto et al., Ivermectin and outcomes from Covid-19 pneumonia: A systematic review and meta-analysis of randomized clinical trial studies, Reviews In Medical Virology, doi:10.1002/rmv.2265.wiley.com, doi.org.

5. Kory et al., Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19, American Journal of Therapeutics, doi:10.1097/MJT.0000000000001377.lww.com, doi.org.

6. Lawrie et al., Ivermectin reduces the risk of death from COVID-19 – a rapid review and meta-analysis in support of the recommendation of the Front Line COVID-19 Critical Care Alliance, Preprint, b3d2650e-e929-4448-a527-4eeb59304c7f.filesusr.com/ugd/593c4f_8cb655bd21b1448ba6cf1f4c59f0d73d.pdf.filesusr.com.

7. Nardelli et al., Crying wolf in time of Corona: the strange case of ivermectin and hydroxychloroquine. Is the fear of failure withholding potential life-saving treatment from clinical use?, Signa Vitae, doi:10.22514/sv.2021.043.signavitae.com, doi.org.

8. reddit.com, www.reddit.com/r/ivermectin/comments/m5kr7b/dr_tess_lawrie_discusses_her_ivermectin/.www.reddit.com/r/ivermectin/comments/m5kr7b/dr_tess_lawrie_discusses_her_ivermectin/.

9. roundingtheearth.substack.com, roundingtheearth.substack.com/p/who-manages-unitaid-context-behind.roundingtheearth.substack.com/p/who-manages-unitaid-context-behind.

10. Schwartz, E., Does ivermectin have a place in the treatment of mild Covid-19?, New Microbes and New Infections, doi:10.1016/j.nmni.2022.100989.sciencedirect.com, doi.org.

11. trialsitenews.com, trialsitenews.com/the-case-of-dr-andrew-hill-was-their-unethical-activity-associated-with-his-ivermectin-meta-analysis-or-just-another-drug-dev-day/.trialsitenews.com/the-case-of-dr-andrew-hill-was-their-unethical-activity-associated-with-his-ivermectin-meta-analysis-or-just-another-drug-dev-day/.

12. worldcouncilforhealth.org, worldcouncilforhealth.org/multimedia/tess-lawrie-conversation-andrew-hill/.worldcouncilforhealth.org/multimedia/tess-lawrie-conversation-andrew-hill/.

13. youtube.com, www.youtube.com/watch?v=y2FWPQm6sxw&t=3s.www.youtube.com/watch?v=y2FWPQm6sxw&t=3s.

14. Zein et al., Ivermectin and mortality in patients with COVID-19: A systematic review, meta-analysis, and meta-regression of randomized controlled trials, Diabetes & Metabolic Syndrome: Clinical Research & Reviews, doi:10.1016/j.dsx.2021.102186.sciencedirect.com, doi.org.

Important missing comments or errors? Let us know.

risk of death, 75.0% lower, RR 0.25, p < 0.001.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Hill et al., 19 Jan 2021, preprint, 40 authors.

This Paper Ivermectin All

Meta-analysis of randomized trials of ivermectin to treat SARS-CoV-2 infection

Dr Andrew Hill, Ahmed S Abdulamir, Sabeena Ahmed, Asma Asghar, Olufemi Emmanuel Babalola, Rabia Basri, Carlos Chaccour, Aijaz Zeeshan Khan Chachar, Abu Tauib Mohammed Chowdhury, Ahmed Elgazzar, Leah Ellis, Jonathan Falconer, Anna Garratt, Basma M Hany, Hashim A Hashim, Wasim Ul Haque, Arshad Hayat, Shuixiang He, Ramin Jamshidian, Wasif Ali Khan, Ravi Kirti, Alejandro Krolewiecki, Carlos Lanusse, Jacob Levi, Reaz Mahmud, Sermand Ahmed Mangat, Kaitlyn Mccann, Anant Mohan, Mortezza Shakshi Niaee, Nurullah Okumus, Victoria Pilkington, Chinmay Saha Podder, Ambar Qavi, Houssam Raad, Mohammaed Sadegh Rezai, Surapaneni Sasank, Veerapaneni Spoorthi, Tejas Suri, Junzheng Wang, Hannah Wentzel

doi:10.21203/rs.3.rs-148845/v1

Forum Infectious Diseases published a version of this preprint. The authors subsequently learned that one of the studies on which this analysis was based had been withdrawn due to fraudulent data. An expression of concern was issued on August 9, 2021.

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