Hong, 30 patient HCQ late treatment PSM study: 25% faster recovery [p=0.45], 13% longer hospitalization [p=0.75], and no change in viral clearance [p=0.99] https://c19p.org/hong2
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Use of combined treatment of 3rd-generation cephalosporin, azithromycin and antiviral agents on moderate SARs-CoV-2 patients in South Korea: A retrospective cohort study
et al., PLOS ONE, doi:10.1371/journal.pone.0267645
Retrospective 25 hospitalized patients treated with cephalosporin, azithromycin, and HCQ, and 217 SOC patients in South Korea, reporting no significant differences. 5 patients receiving lopinavir/ritonavir and HCQ >5 days were excluded for unknown reasons. HCQ was typically initiated based on progression or side effects from another treatment. Conflicting results are reported. Table 2 indicates 15 CA/HCQ patients after matching, while Table S2 shows 25, and the Table 3 count is blank. S2 appears to incorrectly show before matching results, and the after matching results are missing in Table 3. 200mg HCQ bid.
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recovery time, 24.9% lower, HR 0.75, p = 0.45, treatment 15, control 15, inverted to make RR<1 favor treatment, propensity score matching.
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hospitalization time, 12.7% higher, HR 1.13, p = 0.75, treatment 15, control 15, inverted to make RR<1 favor treatment, propensity score matching.
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viral clearance time, 0.5% lower, HR 1.00, p = 0.99, treatment 15, control 15, inverted to make RR<1 favor treatment, propensity score matching.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Hong et al., 4 May 2022, retrospective, South Korea, peer-reviewed, 11 authors, study period 28 February, 2020 - 28 April, 2020.
Contact:
kmedicsoon@pusan.ac.kr, thhwang@pusan.ac.kr, wsabf@naver.com.
Late treatment
is less effective
is less effective
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