Clinical characteristics of 17 patients with COVID-19 and systemic autoimmune diseases: a retrospective study

6/16 Pre-Exposure Prophylaxis study (treated before exposed to the virus)

Huang et al., Annals of the Rheumatic Diseases 2020:79, 1163-1169, doi:10.1136/annrheumdis-2020-217425 (Peer Reviewed)
Clinical characteristics of 17 patients with COVID-19 and systemic autoimmune diseases: a retrospective study

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Analysis of 1255 COVID-19 patients in Wuhan Tongji Hospital finding 0.61% with systemic autoimmune diseases, much lower than authors expected (3%–10%). Authors hypothesise that protective factors, such as CQ/HCQ use, reduce hospitalization.

Huang et al., 6/16/2020, retrospective, China, Asia, peer-reviewed, 15 authors.

risk of hospitalization, 80.0% lower, RR 0.20, p < 0.001, treatment 8, control 1247.

This study is excluded in meta analysis: significant unadjusted confounding possible.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

All 344 studies Meta Analysis

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