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HCQ study #45 of 306
5/25 Late treatment study
Ip et al., PLoS ONE, doi:10.1371/journal.pone.0237693 (Peer Reviewed)
Hydroxychloroquine and Tocilizumab Therapy in COVID-19 Patients - An Observational Study
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Retrospective study of late stage use on 2,512 hospitalized patients showing no significant differences in associated mortality for patients receiving any HCQ during the hospitalization (HR, 0.99 [95% CI, 0.80-1.22]), HCQ alone (HR, 1.02 [95% CI, 0.83-1.27]), or HCQ+AZ (HR, 0.98 [95% CI, 0.75-1.28]). Misclassification is possible due to manual abstraction of EHR data. They observed a change in the prescribing patterns of HCQ during the study timeframe. Confounding by indication.

Ip et al., 5/25/2020, retrospective, database analysis, USA, North America, peer-reviewed, 32 authors.
risk of death, 1.0% lower, RR 0.99, p = 0.93, treatment 432 of 1914 (22.6%), control 115 of 598 (19.2%), adjusted per study.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
All 306 studies    Meta analysis
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