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0 0.5 1 1.5 2+ Case 62% Improvement Relative Risk c19hcq.com Kadnur et al. HCQ for COVID-19 PrEP Favors HCQ Favors control
Kadnur, 358 patient HCQ prophylaxis study: 62% fewer cases [p=0.01] https://c19p.org/kadnur
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Hydroxychloroquine pre-exposure prophylaxis for COVID-19 among healthcare workers: Initial experience from India
Kadnur et al., Journal of Family Medicine and Primary Care, doi:10.4103/jfmpc.jfmpc_1177_21
22 Jul 2020    Source   PDF   Share   Tweet
Prophylaxis study with 334 low-risk healthcare workers in India, showing significantly lower risk of cases with treatment. Symptomatic patients received PCR results, but only some asymptomatic patients did, so there may have been additional asymptomatic cases. There were no severe adverse events.
risk of case, 62.3% lower, RR 0.38, p = 0.01, treatment 10 of 258 (3.9%), control 15 of 100 (15.0%), NNT 9.0, odds ratio converted to relative risk, multivariate logistic regression.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kadnur et al., 7/22/2020, prospective, India, South Asia, peer-reviewed, mean age 31.2, 16 authors, study period 23 April, 2020 - 11 June, 2020.
Contact: manishsoneja@gmail.com.
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