Hydroxychloroquine Pre-Exposure Prophylaxis for COVID-19 Among Healthcare Workers: Initial Experience from India

7/22 Pre-Exposure Prophylaxis study (treated before exposed to the virus)

Kadnur et al., SSRN, doi:10.2139/ssrn.3622350 (Preprint)
Hydroxychloroquine Pre-Exposure Prophylaxis for COVID-19 Among Healthcare Workers: Initial Experience from India

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Prophylaxis study with 334 low-risk healthcare workers in India, showing significantly lower risk of cases with treatment. Symptomatic patients received PCR results, but only some asymptomatic patients did, so there may have been additional asymptomatic cases. There were no severe adverse events.

Kadnur et al., 7/22/2020, prospective, India, South Asia, preprint, 26 authors.

risk of COVID-19 case, 86.3% lower, RR 0.14, p = 0.03, treatment 2 of 248 (0.8%), control 5 of 86 (5.8%), odds ratio converted to relative risk, multivariate logistic regression.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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