In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine

2004 In Vitro

Keyaerts et al., Biochem. Biophys. Res. Comm., 323:1, 8 October 2004, doi:10.1016/j.bbrc.2004.08.085 (Peer Reviewed) (In Vitro)
In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine

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In Vitro study, SARS-CoV-1, not included in the study count or percentages. IC₅₀ of CQ for antiviral activity (8.8) is significantly lower than cytostatic activity CC₅₀ (261.3), selectivity index of 30. IC₅₀ for inhibition of SARS-CoV in vitro approximates the plasma concentrations of CQ reached during treatment of acute malaria. CQ may be considered for immediate use in the prevention and treatment of SARS-CoV infections.

Keyaerts et al., 1/1/2004, peer-reviewed, 5 authors.

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