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0 0.5 1 1.5 2+ Case 51% Improvement Relative Risk c19hcq.com Khurana et al. HCQ for COVID-19 PrEP Favors HCQ Favors control
Khurana, 181 patient HCQ prophylaxis study: 51% fewer cases [p=0.02] https://c19p.org/khurana
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Prevalence and clinical correlates of COVID-19 outbreak among healthcare workers in a tertiary level hospital
Khurana et al., medRxiv, doi:10.1101/2020.07.21.20159301 (Preprint)
24 Jul 2020    Source   PDF   Share   Tweet
Study of hospital health care workers showing HCQ prophylaxis reduces COVID-19 significantly, OR 0.30, p=0.02. 94 positive health care workers with a matched sample of 87 testing negative. Full course prophylaxis was important in this study which used a low dose of 400mg/week HCQ (800mg for week 1), so it may take longer to reach therapeutic levels. Actual benefit of HCQ may be larger because severity of symptoms are not considered here but HCQ may also reduce severity.
risk of case, 51.0% lower, RR 0.49, p = 0.02, treatment 6 of 22 (27.3%), control 88 of 159 (55.3%), NNT 3.6, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Khurana et al., 7/24/2020, retrospective, India, South Asia, preprint, survey, 5 authors.
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