et al., BMJ Open Respiratory Research, doi:10.1136/bmjresp-2020-000646 (Peer Reviewed)
Prospective 56 patients in Uganda, 29 HCQ and 27 control, showing 25.6% faster recovery with HCQ, 6.4 vs. 8.6 days (p
= 0.20). There was no ICU admission, mechanical ventilation, or death.
Treatment delay is not specified but at least a portion of patients appear to have been treated early.
Kirenga et al., 9/9/2020, prospective, Uganda, Africa, peer-reviewed, 29 authors, dosage not specified.
median time to recovery, 25.6% lower, relative time 0.74, p = 0.20, treatment 29, control 27.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.