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All Studies   Meta Analysis   Recent: 
Hydroxychloroquine as an aerosol might markedly reduce and even prevent severe clinical symptoms after SARS-CoV-2 infection
Klimke et al., Med. Hypotheses, doi:10.1016/j.mehy.2020.109783
27 Apr 2020    Source   PDF   Share   Tweet
Proposal to use HCQ as an aerosol in order to reach sufficient therapeutic levels at the alveolar epithelial cells. Authors suggest this will reduce adverse drug reactions compared with oral application, and the increase in tolerability enables a broader use for prevention and post-exposure prophylaxis, which would be an advantage especially for high-risk, multi-morbid and elderly patients. Empirical data on self-medication with a one-week aerosol application is presented, showing inhalation was well tolerated.
Klimke et al., 4/27/2020, peer-reviewed, 4 authors.
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