Retrospective 1,500 hospitalized late stage (median SaO2
87.7) patients in Turkey, showing no significant difference with HCQ treatment.
Kokturk et al., 4/28/2021, retrospective, database analysis, Turkey, Europe, peer-reviewed, 68 authors.
risk of death, 3.8% higher, RR 1.04, p = 0.97, treatment 62 of 1382 (4.5%), control 5 of 118 (4.2%), adjusted per study, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.