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HCQ study #304 of 306
6/4 Late treatment study
Lagier et al., Preprint (Preprint)
Outcomes of 2,111 COVID-19 hospitalised patients treated with 2 hydroxychloroquine/azithromycin and other regimens in Marseille, France: a 3 monocentric retrospective analysis
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Retrospective 2,011 hospitalized patients in France, median age 67, showing lower mortality with HCQ+AZ, and further benefit with the addition of zinc.

Lagier et al., 6/4/2021, retrospective, France, Europe, preprint, 32 authors.
risk of death, 32.0% lower, RR 0.68, p = 0.004, treatment 93 of 1270 (7.3%), control 146 of 841 (17.4%), adjusted per study, weighted multivariate Cox proportional hazards model.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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