Use of glucocorticoids megadoses in SARS-CoV-2 infection in a spanish registry: SEMI-COVID-19
Cristina Lavilla Olleros, Cristina Ausín García, Alejandro David Bendala Estrada, Ana Muñoz, Philip Erick Wikman Jogersen, Ana Fernández Cruz, Vicente Giner Galvañ, Juan Antonio Vargas, José Miguel Seguí Ripoll, Manuel Rubio-Rivas, Rodrigo Miranda Godoy, Luis Mérida Rodrigo, Eva Fonseca Aizpuru, Francisco Arnalich Fernández, Arturo Artero, Jose Loureiro Amigo, Gema María García García, Luis Corral Gudino, Jose Jiménez Torres, José-Manuel Casas-Rojo, Jesús Millán Núñez-Cortés
PLOS ONE, doi:10.1371/journal.pone.0261711
Objective To describe the impact of different doses of corticosteroids on the evolution of patients with COVID-19 pneumonia, based on the potential benefit of the non-genomic mechanism of these drugs at higher doses.
Methods Observational study using data collected from the SEMI-COVID-19 Registry. We evaluated the epidemiological, radiological and analytical scenario between patients treated with megadoses therapy of corticosteroids vs low-dose of corticosteroids and the development of complications. The primary endpoint was all-cause in-hospital mortality according to use of corticosteroids megadoses.
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