1/12 Late treatment study
et al., Research Square, doi:10.21203/rs.3.rs-119202/v1 (Preprint)
Treatment of COVID-19 patients with hydroxychloroquine or chloroquine: A retrospective analysis
Treatment of COVID-19 patients with hydroxychloroquine or chloroquine: A retrospective analysis
Small retrospective database analysis of 37 late stage patients hospitalized in an intensive care center in China, not finding a significant difference in viral shedding. Pateints were all in serious condition. There was only one death however the group is not specified. Confounding by indication is likely.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
Li et al., 1/12/2021, retrospective, database analysis, China, Asia, preprint, 5 authors.
time to viral-, 40.0% higher, relative time 1.40, p = 0.06, treatment 18, control 19.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
