Treatment of COVID-19 patients with hydroxychloroquine or chloroquine: A retrospective analysis

1/12 Late treatment study

Li et al., Research Square, doi:10.21203/rs.3.rs-119202/v1 (Preprint)
Treatment of COVID-19 patients with hydroxychloroquine or chloroquine: A retrospective analysis

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Small retrospective database analysis of 37 late stage patients hospitalized in an intensive care center in China, not finding a significant difference in viral shedding. Pateints were all in serious condition. There was only one death however the group is not specified. Confounding by indication is likely.

Li et al., 1/12/2021, retrospective, database analysis, China, Asia, preprint, 5 authors.

time to viral-, 40.0% higher, relative time 1.40, p = 0.06, treatment 18, control 19.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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