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0 0.5 1 1.5 2+ Discharge 50% Improvement Relative Risk c19hcq.com Li et al. HCQ for COVID-19 LATE TREATMENT Favors HCQ Favors control
Li, 28 patient HCQ late treatment study: 50% higher hospital discharge [p=0.09] https://c19p.org/li3
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Evaluation of the efficacy and safety of hydroxychloroquine in comparison with chloroquine in moderate and severe patients with COVID-19
Li et al., Science China Life Sciences, doi:10.1007/s11427-020-1871-4
18 Jan 2021    Source   PDF   Share   Tweet
Small RCT comparing HCQ and CQ in China with 88 very late stage (17.6 days from onset to hospitalization and ~10 days to randomization) patients. The primary clinical outcomes (TTCR and TTCI) were not significantly different. Authors note that HCQ may have more promising efficacy in immune system modulation, indicated by ferritin reduction in the moderate cases and improvement of CT scores and lymphocyte counts in the severe cases. HCQ and CQ were well tolerated.
Authors also compare RCT patients to a matched sample of non-RCT patients in the same hospital, showing shorter time to discharge with CQ/HCQ, but not statistically significant due to the small size.
risk of no hospital discharge, 50.0% lower, HR 0.50, p = 0.09, treatment 14, control 14, RCT patients vs. matched sample of non-treated patients.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Li et al., 1/18/2021, retrospective, China, Asia, peer-reviewed, 21 authors.
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Late treatment
is less effective
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