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Home   COVID-19 treatment studies for Vitamin D  COVID-19 treatment studies for Vitamin D  C19 studies: Vitamin D  Vitamin D   Select treatmentSelect treatmentTreatmentsTreatments
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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 52% Improvement Relative Risk Mechanical ventilation 32% ICU admission 32% c19vitamind.com/maghbooli.html Favors vitamin D Favors control
25 September 2020 - Analysis of outcomes based on serum levels
Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection
Maghbooli et al., PLOS One, doi:10.1371/journal.pone.0239799 (Peer Reviewed)
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Retrospective 235 hospitalized patients showing a significant association between vitamin D sufficiency and reduction in clinical severity.
For patients over 40, mortality was 9.7% with 25(OH)D levels >30ng/mL, versus 20% for <30ng/mL.
A significant reduction in serum CRP, an inflammatory marker, along with increased lymphocytes percentage suggest that vitamin D sufficiency may help modulate the immune response possibly by reducing the risk for cytokine storm in response to this viral infection.
risk of death, 51.7% lower, RR 0.48, p = 0.08, high D levels 7 of 72 (9.7%), low D levels 27 of 134 (20.1%), NNT 9.6, age >40.
risk of mechanical ventilation, 31.6% lower, RR 0.68, p = 0.49, high D levels 6 of 77 (7.8%), low D levels 18 of 158 (11.4%), NNT 28.
risk of ICU admission, 32.0% lower, RR 0.68, p = 0.33, high D levels 11 of 77 (14.3%), low D levels 33 of 158 (20.9%), NNT 15, >30nmol/L.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Maghbooli et al., 9/25/2020, retrospective, Iran, Middle East, peer-reviewed, 11 authors.
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