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0 0.5 1 1.5 2+ Time to viral- -203% Improvement Relative Risk c19hcq.com Mallat et al. HCQ for COVID-19 LATE TREATMENT Favors HCQ Favors control
Mallat, 34 patient HCQ late treatment study: 203% slower viral clearance [p=0.02] https://c19p.org/mallat
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Hydroxychloroquine is associated with slower viral clearance in clinical COVID-19 patients with mild to moderate disease: A retrospective study
Mallat et al., Medicine (Baltimore), doi:10.1097/MD.0000000000023720 (preprint 5/2)
2 May 2020    Source   PDF   Share   Tweet
Very small retrospective analysis of 34 patients finding slower binary PCR viral clearance with HCQ. No information on severity for treatment versus control is provided. No deaths, ICU admission, or mechanical ventilation. Binary PCR does not distinguish replication-competence. HCQ treatment started very late for many patients with >= 9 days for 25%.
time to viral-, 203.0% higher, relative time 3.03, p = 0.02, treatment 23, control 11.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mallat et al., 5/2/2020, retrospective, United Arab Emirates, Middle East, peer-reviewed, 8 authors, average treatment delay 4.0 days.
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is less effective
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