Hydroxychloroquine as pre-exposure prophylaxis against COVID-19 in health-care workers: A single-center experience

11/6 Pre-Exposure Prophylaxis study (treated before exposed to the virus)

Mathai et al., J. Marine Medical Society, doi:10.4103/jmms.jmms_115_20 (Peer Reviewed)
Hydroxychloroquine as pre-exposure prophylaxis against COVID-19 in health-care workers: A single-center experience

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90% reduction in cases with HCQ pre-exposure prophylaxis. Retrospective 604 healthcare workers.

Mathai et al., 11/6/2020, retrospective, India, South Asia, peer-reviewed, 3 authors.

risk of COVID-19 case, 89.5% lower, RR 0.10, p < 0.001, treatment 10 of 491 (2.0%), control 22 of 113 (19.5%).

risk of COVID-19 case, 88.5% lower, RR 0.12, p < 0.001, treatment 5 of 491 (1.0%), control 10 of 113 (8.8%), symptomatic.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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