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0 0.5 1 1.5 2+ Mortality 55% Improvement Relative Risk c19hcq.com Membrillo de Novales et al. HCQ LATE TREATMENT Favors HCQ Favors control
Membrillo de Novales, 166 patient HCQ late treatment study: 55% lower mortality [p=0.002] https://c19p.org/membrillo
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Early Hydroxychloroquine Is Associated with an Increase of Survival in COVID-19 Patients: An Observational Study
Membrillo de Novales et al., Preprints 2020, 2020050057, doi:10.20944/preprints202005.0057.v1 (Preprint)
5 May 2020    Source   PDF   Share   Tweet
166 patients hospitalised with COVID-19, HCQ increased survival 1.4 - 1.8 times when patients admitted in early stages. Early is relative to hospital admission here - all patients were in relatively serious condition.
risk of death, 55.1% lower, RR 0.45, p = 0.002, treatment 27 of 123 (22.0%), control 21 of 43 (48.8%), NNT 3.7.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Membrillo de Novales et al., 5/5/2020, retrospective, Spain, Europe, preprint, 19 authors, average treatment delay 7.0 days.
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Late treatment
is less effective
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