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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 35% Improvement Relative Risk c19hcq.com/menardi.html Favors HCQ Favors control
30 September 2021 - Late treatment study
A retrospective analysis on pharmacological approaches to COVID-19 patients in an Italian hub hospital during the early phase of the pandemic
Menardi et al., PharmAdvances, doi:10.36118/pharmadvances.2021.15 (Peer Reviewed)
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Retrospective 277 hospitalized patients in Italy, showing lower mortality with HCQ treatment, not reaching statistical significance, and subject to confounding by indication.
risk of death, 35.2% lower, RR 0.65, p = 0.12, treatment 32 of 200 (16.0%), control 19 of 77 (24.7%), NNT 12.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
This study is excluded in the after exclusion results of meta analysis: excessive unadjusted differences between groups, substantial unadjusted confounding by indication likely.
Menardi et al., 9/30/2021, retrospective, Italy, Europe, peer-reviewed, 10 authors.
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