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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Hospitalization 46% Improvement Relative Risk Case 28% Vitamin D for COVID-19  Merzon et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 7,807 patients in Israel Fewer cases with higher vitamin D levels (p=0.001) c19early.org Merzon et al., The FEBS J., July 2020 Favors vitamin D Favors control

Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study

Merzon et al., The FEBS Journal, doi:doi.org/10.1111/febs.15495
Jul 2020  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 7 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,900+ studies for 60+ treatments. c19early.org
Analysis of 7,807 patients finding that low vitamin D levels are correlated with increased risk of cases and hospitalization. Adjusted odds ratio OR for sufficient vitamin D level for cases 0.69, p < 0.001, and for hospitalization 0.51, p = 0.061.
This is the 6th of 194 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 2470 vigintillion).
risk of hospitalization, 46.4% lower, RR 0.54, p = 0.06, high D levels 79, low D levels 703, odds ratio converted to relative risk, >30ng/mL.
risk of case, 28.4% lower, RR 0.72, p < 0.001, high D levels 1,139, low D levels 6,668, odds ratio converted to relative risk, >30ng/mL.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Merzon et al., 23 Jul 2020, retrospective, Israel, peer-reviewed, 3 authors.
This PaperVitamin DAll
Low plasma 25(OH) vitamin D level is associated with increased risk of COVID‐19 infection: an Israeli population‐based study
Eugene Merzon, Dmitry Tworowski, Alessandro Gorohovski, Shlomo Vinker, Avivit Golan Cohen, Ilan Green, Milana Frenkel‐morgenstern
The FEBS Journal, doi:10.1111/febs.15495
Vitamin D deficiency is a worldwide pandemic. The aim of this study was to evaluate associations of plasma 25(OH)D levels with the likelihood of coronavirus disease 2019 (COVID-19) infection and hospitalization. The study population included the 14 000 members of Leumit Health Services, who were tested for COVID-19 infection from February 1 st to April 30 th , 2020, and who had at least one previous blood test for the plasma 25(OH) D level. 'Suboptimal' or 'low' plasma 25(OH)D level was defined as plasma 25-hydroxyvitamin D, or 25(OH)D, concentration below the level of 30 ng/mL. Of 7807 individuals, 782 (10.02%) were COVID-19-positive, and 7025 (89.98%) COVID-19-negative. The mean plasma vitamin D level was significantly lower among those who tested positive than negative for COVID-19 [19.00 ng/mL (95% confidence interval (CI) 18. ]. Univariate analysis demonstrated an association between the low plasma 25(OH)D level and increased likelihood of COVID-19 infection [crude odds ratio (OR) of 1.58 (95% CI: 1.24-2.01, P < 0.001)], and of hospitalization due to the SARS-CoV-2 virus [crude OR of 2.09 (95% CI: 1.01-4.30, P < 0.05)]. In multivariate analyses that controlled for demographic variables, and psychiatric and somatic disorders, the adjusted OR of COVID-19 infection [1.45 (95% CI: 1.08-1.95, P < 0.001)] and of hospitalization due to the SARS-CoV-2 virus [1.95 (95% CI: 0.98-4.845, P = 0.061)] were preserved. In the multivariate analyses, age over 50 years, male gender and low-medium socioeconomic status were also positively associated with the risk of COVID-19 infection; age over 50 years was positively associated with the likelihood of hospitalization due to COVID-19. We concluded that low plasma 25(OH)D levels appear to be an independent risk factor for COVID-19 infection and hospitalization.
Abbreviations BMI, body mass index; COVID-19-N, COVID-19-negative; COVID-19-P, COVID-19-positive; LHS, Leumit Health Services; SES, socioeconomic status. Authors' contribution EM, MFM, DT, IG, AVG and SV designed the project and contributed the research questions, EM, DT, MFM and IG performed data mining and analysed results. EM performed statistical analysis. MFM, EM and DT wrote and edited the manuscript. MFM, AG and DT presented results in visual forms, MFM and EM supervised the project, and both contributed to the project design. All the authors contributed to editing of the manuscript. No honorarium, grant or other form of payment was given to any of the authors to produce the manuscript. Conflict of interest The authors declare no conflict of interest. Ethical considerations This is a data-based study, and as such, has no clinical trial registration number. The study received approval from the Leumit Health Services research committee and the Shamir Medical Centre IRB.
References
Adhikari, Meng, Wu, Mao, Ye et al., Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review, Infect Dis Poverty
Ali, Baloch, Ahmed, Ali, Iqbal, The outbreak of Coronavirus Disease 2019 (COVID-19)-An emerging global health threat, J Infect Public Health
Almerie, Kerrigan, The association between obesity and poor outcome after COVID-19 indicates a potential therapeutic role for montelukast, Med Hypotheses
Alqahtani, Oyelade, Aldhahir, Alghamdi, Almehmadi et al., Prevalence, severity and mortality associated with COPD and smoking in patients with COVID-19: a rapid systematic review and metaanalysis, PLoS One
Cao, Wu, Faucon, Sabatier, SARS-CoV-2 & Covid-19: Key-Roles of the 'Renin-Angiotensin' System / Vitamin D Impacting Drug and Vaccine Developments, Infect Disord Drug Targets
Carr, A new clinical trial to test high-dose vitamin C in patients with COVID-19, Crit Care
Carter, Baranauskas, Fly, Considerations for obesity, vitamin D, and physical activity amidst the COVID-19 pandemic, Obesity (Silver Spring)
Cattaruzza, Zagà, Gallus, Argenio, Gorini, smoking and COVID-19 pandemic: old and new issues. A summary of the evidence from the scientific literature, Acta Biomed
Chakladar, Shende, Li, Rajasekaran, Chang et al., Smoking-mediated upregulation of the androgen pathway leads to increased SARS-CoV-2 susceptibility, Int J Mol Sci
Cheng, Can early and high intravenous dose of vitamin C prevent and treat coronavirus disease 2019 (COVID-19)?, Med Drug Discov
De Oliveira, De Azevedo, Da Mota Santana, Sales, Pereira-Santos, Obesity and overweight decreases the effect of vitamin D supplementation in adults: systematic review and metaanalysis of randomized controlled trials, Rev Endocr Metab Disord
Ekiz, Pazarlı, Relationship between COVID-19 and obesity, Diabetes Metab Syndr
French, Gorgi, Ihenetu, Weeks, Lynch et al., Vitamin D status of county hospital patients assessed by the DiaSorin LIAISON ® 25-hydroxyvitamin D assay, Clin Chim Acta
Ganatra, Hammond, Nohria, The novel coronavirus disease (COVID-19) threat for patients with cardiovascular disease and cancer, JACC CardioOncol
Gao, Zheng, Wang, Sun, Pan et al., Obesity Is a Risk Factor for Greater COVID-19 Severity, Diabetes Care
Garassino, Whisenant, Huang, Trama, Torri et al., COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study, Lancet Oncol
Garg, Al-Ani, Mitchell, Hendy, Christensen, Editorial: low population mortality from COVID-19 in countries south of latitude 35 degrees North -supports vitamin D as a factor determining severity. Authors' reply, Aliment Pharmacol Ther
Gennaro, Pizzol, Marotta, Antunes, Racalbuto et al., Coronavirus diseases (COVID-19) current status and future perspectives: a narrative review, Int J Environ Res Public Health
Golan-Cohen, Merzon, Alhin, Kitai, Fogelman, Blood levels of vitamin D and health-functional status in asymptomatic individuals: a cross sectional study, J Eval Clin Pract
Grant, Lahore, Mcdonnell, Baggerly, French et al., Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths, Nutrients
Grant, Mcdonnell, Hastie, Letter in response to the article: Vitamin D concentrations and COVID-19 infection in UK biobank, Diabetes Metab Syndr
Hastie, Mackay, Ho, Celis-Morales, Katikireddi et al., Vitamin D concentrations and COVID-19 infection in UK Biobank, Diabetes Metab Syndr
Holick, The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention, Rev Endocr Metab Disord
Hussain, Vasas, El-Hasani, Letter to the Editor: Obesity as a risk factor for greater severity of COVID-19 in patients with metabolic associated fatty liver disease, Metabolism
Ilie, Stefanescu, Smith, The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality, Aging Clin Exp Res
Jakovac, COVID-19 and vitamin D-Is there a link and an opportunity for intervention?, Am J Physiol Endocrinol Metab
Jj, Active smoking and severity of coronavirus disease 2019 (COVID-19): differences in measurement of variables could cause errors in the results, Eur J Intern Med
Kaur, Lungarella, Rahman, SARS-CoV-2 COVID-19 susceptibility and lung inflammatory storm by smoking and vaping, J Inflamm (Lond)
Leung, Yang, Sin, Reply to: "Current smoking is not associated with COVID-19, Eur Respir J
Li, He, Yuan, Zhang, Li et al., Meta-analysis investigating the relationship between clinical features, outcomes, and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia, Am J Infect Control, doi:10.1016/j.ajic.2020.06.008
Llewellyn, Lang, Langa, Muniz-Terrera, Phillips et al., Vitamin D and risk of cognitive decline in elderly persons, Arch Intern Med
Martineau, Jolliffe, Greenberg, Aloia, Bergman et al., Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis, Health Technol Assess
Martineau, Jolliffe, Hooper, Greenberg, Aloia et al., Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data, BMJ
Mccartney, Byrne, Optimisation of vitamin D status for enhanced immuno-protection against Covid-19, Ir Med J
Meltzer, Best, Zhang, Vokes, Arora et al., Association of vitamin D deficiency and treatment with COVID-19 incidence, medRxiv, doi:10.1101/2020.05.08.20095893
Mif, Binkley, Bischoff-Ferrari, Gordon, Hanley et al., Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline, J Clin Endocrinol Metab
Molloy, Murphy, Vitamin D, Covid-19 and children, Ir Med J
Moure, Rando-Segura, Gimferrer, Roig, Pumarola et al., Evaluation of the novel DiaSorin LIAISON, Enferm Infecc Microbiol Clin
Panarese, Shahini, Letter: Covid-19, and vitamin D, Aliment Pharmacol Ther
Panfili, Roversi, Argenio, Rossi, Cappa et al., Possible role of vitamin D in Covid-19 infection in pediatric population, J Endocrinol Invest
Perski, Herbeć, Shahab, Brown, Influence of the SARS-CoV-2 outbreak on the uptake of a popular smoking cessation app in UK smokers: interrupted time series analysis, JMIR Mhealth Uhealth
Pringle, Ward, Chilvers, Assessment of the completeness and accuracy of computer medical records in four practices committed to recording data on computer, Br J Gen Pract
Quesada-Gomez, Castillo, Bouillon, Vitamin D Receptor stimulation to reduce Acute Respiratory Distress Syndrome (ARDS) in patients with Coronavirus SARS-CoV-2 infections: Revised Ms SBMB 2020_166, J Steroid Biochem Mol Biol, doi:10.1016/j.jsbmb.2020.105719
Raisi-Estabragh, Mccracken, Bethell, Cooper, Cooper et al., Greater risk of severe COVID-19 in Black, Asian and Minority Ethnic populations is not explained by cardiometabolic, socioeconomic or behavioural factors, or by 25(OH)-vitamin D status: study of 1326 cases from the UK Biobank, J Public Health (Oxf), doi:10.1093/pubmed/fdaa095
Rennert, Peterburg, Prevalence of selected chronic diseases in Israel, Isr Med Assoc J
Rhodes, Subramanian, Laird, Kenny, Editorial: low population mortality from COVID-19 in countries south of latitude 35 degrees North supports vitamin D as a factor determining severity, Aliment Pharmacol Ther
Ribeiro, Santana, Oliver, Rond Ó Phc, Mendes et al., Does Vitamin D play a role in the management of Covid-19 in Brazil?, Rev Saude Publica
Rosecrans, Dohnal, Seasonal vitamin D changes and the impact on health risk assessment, Clin Biochem
Rossato, Russo, Mazzocut, Vincenzo, Fioretto et al., Current smoking is not associated with COVID-19, Eur Respir J
Roy, Matson, Herlekar, Response to 'Vitamin D concentrations and COVID-19 infection in UK Biobank', Diabetes Metab Syndr
Russo, Bonassi, Giacconi, Malavolta, Tomino et al., COVID-19 and smoking: is nicotine the hidden link?, Eur Respir J
Shalev, Chodick, Goren, Silber, Kokia et al., The use of an automated patient registry to manage and monitor cardiovascular conditions and related outcomes in a large health organization, Int J Cardiol
Sharif-Askari, Sharif-Askari, Alabed, Temsah, Heialy et al., Airways expression of SARS-CoV-2 receptor, ACE2, and TMPRSS2 is lower in children than adults and increases with smoking and COPD, Mol Ther Methods Clin Dev
Sievert, Interactive Web-Based Data Visualization with R, plotly, and shiny
Silberstein, Vitamin D: A simpler alternative to tocilizumab for trial in COVID-19?, Med Hypotheses
Sokouti, Sadeghi, Pashazadeh, Eslami, Ghojazadeh et al., Comparative global epidemiological investigation of SARS-CoV-2 and SARS-CoV diseases using meta-MUMS tool through incidence, mortality, and recovery rates, Arch Med Res
Team, Preliminary estimates of the prevalence of selected underlying health conditions among patients with coronavirus disease 2019 -United States, February 12, MMWR Morb Mortal Wkly Rep
Thuzar, Young, Ahmed, Ward, Wolley et al., Diagnosis of primary aldosteronism by seated saline suppression testvariability between immunoassay and HPLC-MS/MS, J Clin Endocrinol Metab
Tian, Rong, Letter: Covid-19, and vitamin D. Authors' reply, Aliment Pharmacol Ther
Torjesen, Covid-19: Public health agencies review whether vitamin D supplements could reduce risk, BMJ
Vieth, What is the optimal vitamin D status for health?, Prog Biophys Mol Biol
Weir, Thenappan, Bhargava, Chen, Does vitamin D deficiency increase the severity of COVID-19?, Clin Med (Lond)
Wu, Zhao, Yu, Chen, Song et al., A new coronavirus associated with human respiratory disease in China, Nature
Zemb, Bergman, Camargo, Cavalier, Cormier et al., Vitamin D deficiency and the COVID-19 pandemic, J Glob Antimicrob Resist
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