6/30 Late treatment study
et al., J. Gen. Intern. Med., doi:10.1007/s11606-020-05983-z (Peer Reviewed)
Risk Factors for Mortality in Patients with COVID-19 in New York City
Risk Factors for Mortality in Patients with COVID-19 in New York City
HCQ decreases mortality, HR 0.53 (CI 0.41–0.67). IPTW adjustment does not significantly change HR 0.53 (0.41-0.68). Retrospective 6,000 patients in New York City.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
Mikami et al., 6/30/2020, retrospective, USA, North America, peer-reviewed, 7 authors.
risk of death, 47.0% lower, RR 0.53, p < 0.001, treatment 575 of 2077 (27.7%), control 231 of 743 (31.1%), adjusted per study.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
