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HCQ study #298 of 306
5/27 Early treatment study
Million et al., Preprint (Preprint)
Early Treatment with Hydroxychloroquine and Azithromycin in 10,429 COVID-19 Outpatients: A Monocentric Retrospective Cohort Study
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Retrospective 10,429 outpatients in France, 8,315 treated with HCQ+AZ a median of 4 days from symptom onset, showing significantly lower mortality with treatment.

Million et al., 5/27/2021, retrospective, France, Europe, preprint, 28 authors, dosage 200mg tid days 1-10.
risk of death, 83.0% lower, RR 0.17, p < 0.001, treatment 5 of 8315 (0.1%), control 11 of 2114 (0.5%), adjusted per study.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
All 306 studies    Meta analysis
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