Retrospective 213 hospitalized patients in Czech Republic showing lower mortality with HCQ. Subject to confounding by indication.
Modrák et al., 12/4/2020, retrospective, Czech Republic, Europe, preprint, 26 authors.
risk of death, 59.0% lower, RR 0.41, p = 0.04, treatment 108, control 105, Cox (single).
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.
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