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0 0.5 1 1.5 2+ Mortality -81% Improvement Relative Risk c19hcq.com Mohandas et al. HCQ for COVID-19 LATE TREATMENT Favors HCQ Favors control
Mohandas, 3,345 patient HCQ late treatment study: 81% higher mortality [p=0.007] https://c19p.org/mohandas
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Clinical review of COVID-19 patients presenting to a quaternary care private hospital in South India: A retrospective study
Mohandas et al.,
26 Apr 2021    Source   PDF   Share   Tweet
Retrospective 3,345 hospitalized patients in India, 11.5% treated with HCQ, showing unadjusted higher mortality with treatment. Confounding by indication and time based confounding (due to declining use over the period when overall treatment protocols improved dramatically) are likely.
risk of death, 81.0% higher, RR 1.81, p = 0.007, treatment 27 of 384 (7.0%), control 115 of 2,961 (3.9%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: substantial unadjusted confounding by indication likely, unadjusted results with no group details, substantial confounding by time likely due to declining usage over the early stages of the pandemic when overall treatment protocols improved dramatically.
Mohandas et al., 4/26/2021, retrospective, India, South Asia, peer-reviewed, 6 authors.
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Late treatment
is less effective
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