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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Symptomatic case 24% Improvement Relative Risk Symptomatic case (b) 29% c19hcq.com/naggie.html Favors HCQ Favors control
25 August 2021 - Pre-Exposure Prophylaxis study (treated before exposed to the virus)
Hydroxychloroquine for pre-exposure prophylaxis of COVID-19 in health care workers: a randomized, multicenter, placebo-controlled trial (HERO-HCQ)
Naggie et al., medRxiv, doi:10.1101/2021.08.19.21262275 (Preprint)
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RCT 1,360 healthcare workers in the USA showing OR 0.75 [0.49-1.15] for confirmed or suspected COVID-19 clinical infection by day 30. There were no significant safety issues. Authors note that pooling the results with the COVID PREP study gives OR 0.74 [0.55-1.0] p = 0.046. NCT04334148.
risk of symptomatic case, 23.5% lower, RR 0.76, p = 0.18, treatment 41 of 683 (6.0%), control 53 of 676 (7.8%), NNT 54, odds ratio converted to relative risk, logistic regression.
risk of symptomatic case, 29.3% lower, RR 0.71, p = 0.18, treatment 41 of 683 (6.0%), control 53 of 676 (7.8%), NNT 54, odds ratio converted to relative risk, Mantel–Haenszel.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Naggie et al., 8/25/2021, Randomized Controlled Trial, USA, North America, preprint, 22 authors.
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