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0 0.5 1 1.5 2+ Mortality 92% unadjusted Improvement Relative Risk Hospitalization 12% c19hcq.com Oku et al. HCQ for COVID-19 PrEP Favors HCQ Favors control
Oku, 220 patient HCQ prophylaxis study: 92% lower mortality [p=1] and 12% lower hospitalization [p=0.34] https://c19p.org/oku
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Risk factors for hospitalization or mortality for COVID-19 in patients with rheumatic diseases: Results of a nation-wide JCR COVID-19 registry in Japan
Oku et al., Modern Rheumatology, doi:10.1093/mr/roac104
6 Sep 2022    Source   PDF   Share   Tweet
Retrospecttive 220 COVID-19 patients with rheumatic disease in Japan, showing lower mortality and hospitalization with HCQ prophylaxis, without statistical significance.
risk of death, 92.2% lower, RR 0.08, p = 1.00, treatment 0 of 14 (0.0%), control 11 of 206 (5.3%), NNT 19, unadjusted, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of hospitalization, 11.5% lower, RR 0.88, p = 0.34, treatment 9 of 14 (64.3%), control 177 of 206 (85.9%), NNT 4.6, adjusted per study, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Oku et al., 6 Sep 2022, retrospective, Japan, peer-reviewed, 8 authors, study period 3 June, 2020 - 30 June, 2021.
Contact: horiuchi.takahiko.191@m.kyushu-u.ac.jp.
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