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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Hospitalization 12% Improvement Relative Risk Symptomatic at day 21 26% Ct<=40 at day 14 -10% c19hcq.com Omrani et al. HCQ for COVID-19 RCT EARLY TREATMENT Favors HCQ Favors control
Omrani, 456 patient HCQ early treatment RCT: 12% lower hospitalization [p=1], 26% improved recovery [p=0.58], and 10% worse viral clearance [p=0.13] https://c19p.org/omrani
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Randomized double-blinded placebo-controlled trial of hydroxychloroquine with or without azithromycin for virologic cure of non-severe Covid-19
Omrani et al., EClinicalMedicine, doi:10.1016/j.eclinm.2020.100645
20 Nov 2020    Source   PDF   Share   Tweet
Low risk patient RCT for HCQ+AZ and HCQ vs. control, not showing any significant differences.
Authors note that the results are not applicable to higher risk patients, that positive PCR may simply reflect detection of inactive (non-infectious) viral remnants, that an alternative dosage regimen may be more effective, and that medication adherence was unknown.
HCQ dosing was 600mg/day for 1 week, therapeutic levels may not be reached for several days. There were no deaths or serious adverse events.
risk of hospitalization, 12.5% lower, RR 0.88, p = 1.00, treatment 7 of 304 (2.3%), control 4 of 152 (2.6%), NNT 304, HCQ+AZ or HCQ vs. control.
risk of symptomatic at day 21, 25.8% lower, RR 0.74, p = 0.58, treatment 9 of 293 (3.1%), control 6 of 145 (4.1%), NNT 94, HCQ+AZ or HCQ vs. control.
risk of Ct<=40 at day 14, 10.3% higher, RR 1.10, p = 0.13, treatment 223 of 295 (75.6%), control 98 of 143 (68.5%), HCQ+AZ or HCQ vs. control.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Omrani et al., 11/20/2020, Randomized Controlled Trial, Qatar, Middle East, peer-reviewed, 19 authors, dosage 600mg days 1-6, this trial uses multiple treatments in the treatment arm (combined with AZ) - results of individual treatments may vary.
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