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0 0.5 1 1.5 2+ Hospitalization -215% Improvement Relative Risk Symptomatic case -40% Case -5% c19hcq.com Oztas et al. HCQ for COVID-19 PrEP Favors HCQ Favors control
Oztas, 650 patient HCQ prophylaxis study: 215% higher hospitalization [p=0.36], 40% more symptomatic cases [p=0.44], and 5% more cases [p=0.88] https://c19p.org/oztas
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Frequency and Severity of COVID-19 in Patients with Various Rheumatic Diseases Treated Regularly with Colchicine or Hydroxychloroquine
Oztas et al., Journal of Medical Virology, doi:10.1002/jmv.27731
21 Mar 2022    Source   PDF   Share   Tweet
Retrospective 317 HCQ users and 333 household contacts, showing higher risk with HCQ.
Authors do not adjust for the very different baseline risk for systemic autoimmune disease patients. Other research shows that the risk of COVID-19 for systemic autoimmune disease patients is much higher overall, Ferri et al. show OR 4.42, p<0.001 [Ferri].
risk of hospitalization, 215.1% higher, RR 3.15, p = 0.36, treatment 3 of 317 (0.9%), control 1 of 333 (0.3%).
risk of symptomatic case, 40.1% higher, RR 1.40, p = 0.44, treatment 16 of 317 (5.0%), control 12 of 333 (3.6%).
risk of case, 5.0% higher, RR 1.05, p = 0.88, treatment 22 of 317 (6.9%), control 22 of 333 (6.6%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: not adjusting for the different baseline risk of systemic autoimmune patients, excessive unadjusted differences between groups.
Oztas et al., 3/21/2022, retrospective, Turkey, Europe, peer-reviewed, 15 authors.
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