A Prospective Longitudinal Study Evaluating The Influence of Immunosuppressives and Other Factors On COVID-19 in Autoimmune Rheumatic Diseases

8/24 Pre-Exposure Prophylaxis study (treated before exposed to the virus)

Patil et al., Research Square, doi:10.21203/rs.3.rs-805748/v1 (Preprint)
A Prospective Longitudinal Study Evaluating The Influence of Immunosuppressives and Other Factors On COVID-19 in Autoimmune Rheumatic Diseases

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Prospective study of 9,212 autoimmune rheumatic disease patients showing lower mortality with HCQ, without reaching statistical significance. Authors incorrectly state "HCQ use did not influence occurrence of COVID-19 (RR = 0.909, CI (0.715,1.154), p = 0.432) or mortality (p = 0.097)" [1]. CFR for the autoimmune rheumatic disease patients was 4.6 times higher than in the general population from the same area.

Patil et al., 8/24/2021, prospective, India, South Asia, preprint, 20 authors.

risk of death, 65.9% lower, RR 0.34, p = 0.10, treatment 5266, control 3946.

risk of COVID-19 case, 9.1% lower, RR 0.91, p = 0.43, treatment 167 of 5266 (3.2%), control 147 of 3946 (3.7%), adjusted per study.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

[1] nature.com/articles/d41586-019-00857-9

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