Early versus late acute kidney injury among patients with COVID-19

12/4 Late treatment study

Peng et al., Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfaa288 (Peer Reviewed)
Early versus late acute kidney injury among patients with COVID-19—a multicenter study from Wuhan, China

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Retrospective 4020 hospitalized patients in China showing non-statistically significant lower risk of acute kidney injury with HCQ.

Peng et al., 12/4/2020, retrospective, China, Asia, peer-reviewed, 21 authors.

risk of disease progression, 10.8% lower, RR 0.89, p = 0.63, treatment 29 of 453 (6.4%), control 256 of 3567 (7.2%), CQ/HCQ risk of AKI.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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