Restrospective 890 cancer patients with COVID-19, adjusted mortality HR for HCQ/CQ 0.41, p
Confirmed SARS-CoV-2 infection was required, which may help focus on more severe cases. Analysis with Cox proportional hazard model. Potential unmeasured confounders.
Pinato et al., 8/18/2020, retrospective, multiple countries, Europe, peer-reviewed, 64 authors.
risk of death, 59.0% lower, RR 0.41, p < 0.001, treatment 30 of 182 (16.5%), control 181 of 446 (40.6%).
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.