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0 0.5 1 1.5 2+ Symptomatic case 51% primary Improvement Relative Risk Case 27% c19hcq.com Polo et al. NCT04334928 EPICOS HCQ RCT PrEP Favors HCQ Favors control
Polo, 435 patient HCQ prophylaxis RCT: 51% fewer symptomatic cases [p=0.79] and 27% fewer cases [p=0.31] https://c19p.org/polo
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Daily tenofovir disoproxil fumarate/emtricitabine and hydroxychloroquine for pre-exposure prophylaxis of COVID-19: a double-blind placebo controlled randomized trial in healthcare workers
Polo et al., Clinical Microbiology and Infection, doi:10.1016/j.cmi.2022.07.006, EPICOS, NCT04334928 (history)
5 Aug 2022    Source   PDF   Share   Tweet
Early terminated healthcare worker prophylaxis RCT in Spain, showing lower risk of symptomatic cases with HCQ prophylaxis, without statistical significance due to the small number of events.
risk of symptomatic case, 51.0% lower, RR 0.49, p = 0.79, treatment 3 of 224 (1.3%), control 5 of 211 (2.4%), NNT 97, Kaplan–Meier, primary outcome.
risk of case, 27.0% lower, RR 0.73, p = 0.31, treatment 21 of 224 (9.4%), control 23 of 211 (10.9%), Kaplan–Meier.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Polo et al., 8/5/2022, Double Blind Randomized Controlled Trial, placebo-controlled, Spain, peer-reviewed, median age 38.0, 189 authors, trial NCT04334928 (history) (EPICOS).
Contact: jamo@sanidad.gob.es.
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