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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Virological cure 66% Improvement Relative Risk c19hcq.com/purwati.html Favors HCQ Favors control
9 February 2021 - Late treatment study
A Randomized, Double-Blind, Multicenter Clinical Study Comparing the Efficacy and Safety of a Drug Combination of Lopinavir/Ritonavir-Azithromycin, Lopinavir/Ritonavir-Doxycycline, and Azithromycin-Hydroxychloroquine for Patients Diagnosed with Mild to Moderate COVID-19 Infections
Purwati et al., Biochemistry Research International, doi:10.1155/2021/6685921 (Peer Reviewed)
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RCT 754 patients comparing HCQ+AZ along with other treatment groups using lopinavir/ritonavir and doxycycline to a control group taking AZ, finding significantly faster viral clearance with all treatment groups. (The labels in Figure 2 appear to be reversed).
risk of no virological cure, 66.3% lower, RR 0.34, p < 0.001, treatment 38 of 121 (31.4%), control 111 of 119 (93.3%), NNT 1.6, day 7.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Purwati et al., 2/9/2021, Double Blind Randomized Controlled Trial, Indonesia, South Asia, peer-reviewed, 12 authors.
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