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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Symptomatic case 82% Improvement Relative Risk Symptomatic case (b) 88% Case 29% c19hcq.com Raabe et al. NCT04354870 HCQ PrEP Favors HCQ Favors control
Raabe, 130 patient HCQ prophylaxis study: 82% fewer symptomatic cases [p=0.17] https://c19p.org/raabe
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Hydroxychloroquine pre-exposure prophylaxis to prevent SARS-CoV-2 among health care workers at risk for SARS-CoV-2 exposure: A nonrandomized controlled trial
Raabe et al., medRxiv, doi:10.1101/2022.07.01.22277058 (Preprint), NCT04354870 (history)
3 Jul 2022    Source   PDF   Share   Tweet
Small prophylaxis study with 130 healthcare workers in the USA, showing lower symptomatic cases with HCQ prophylaxis, without statistical significance. HCQ participants were significantly older. The only symptomatic HCQ patient reported headache only as a potential COVID-19 symptom.
risk of symptomatic case, 82.2% lower, RR 0.18, p = 0.17, treatment 1 of 59 (1.7%), control 2 of 21 (9.5%), NNT 13.
risk of symptomatic case, 88.4% lower, RR 0.12, p = 0.07, treatment 0 of 59 (0.0%), control 2 of 21 (9.5%), NNT 10, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), fever.
risk of case, 28.8% lower, RR 0.71, p = 0.65, treatment 4 of 59 (6.8%), control 2 of 21 (9.5%), NNT 36, seroconversion.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Raabe et al., 7/3/2022, prospective, USA, preprint, 7 authors, trial NCT04354870 (history).
Contact: vanessa.raabe@nyulangone.org.
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