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0 0.5 1 1.5 2+ Mortality -57% Improvement Relative Risk Ventilation -115% 9-point scale clinical status -147% c19hcq.com Réa-Neto et al. NCT04420247 HCQ RCT LATE TREATMENT Favors HCQ Favors control
Réa-Neto, 105 patient HCQ late treatment RCT: 57% higher mortality [p=0.2], 115% higher ventilation [p=0.03], and 147% worse recovery [p=0.02] https://c19p.org/reanato
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An open-label randomized controlled trial evaluating the efficacy of chloroquine/hydroxychloroquine in severe COVID-19 patients
Réa-Neto et al., Scientific Reports, doi:10.1038/s41598-021-88509-9
27 Apr 2021    Source   PDF   Share   Tweet
Early terminated very late stage (99% on oxygen, 81% in ICU, 18% on mechanical ventilation at baseline) RCT with 24 CQ patients, 29 HCQ, and 52 control patients, showing worse clinical outcomes with treatment. NCT04420247.
risk of death, 57.0% higher, RR 1.57, p = 0.20, treatment 16 of 53 (30.2%), control 10 of 52 (19.2%).
risk of mechanical ventilation, 115.0% higher, RR 2.15, p = 0.03, treatment 53, control 52.
9-point scale clinical status, 147.0% higher, OR 2.47, p = 0.02, treatment 53, control 52, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Réa-Neto et al., 4/27/2021, Randomized Controlled Trial, Brazil, South America, peer-reviewed, 6 authors, average treatment delay 8.0 days, trial NCT04420247.
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Late treatment
is less effective
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