11/28 Late treatment study
et al., International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2020.106249 (Peer Reviewed)
COVID-19 in hospitalized patients in Spain: a cohort study in Madrid
COVID-19 in hospitalized patients in Spain: a cohort study in Madrid
Retrospective 1255 patients in Spain showing lower mortality with HCQ. Subject to confounding by indication.
Rodriguez-Gonzalez et al., 11/28/2020, retrospective, Spain, Europe, peer-reviewed, 20 authors.
risk of death, 22.8% lower, RR 0.77, p = 0.26, treatment 251 of 1,148 (21.9%), control 17 of 60 (28.3%).
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.
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