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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Symp. case 82% Improvement Relative Risk HCQ  Rojas-Serrano et al.  Prophylaxis  DB RCT Is pre-exposure prophylaxis with HCQ beneficial for COVID-19? Double-blind RCT 127 patients in Mexico (April 2020 - March 2021) Fewer symptomatic cases with HCQ (not stat. sig., p=0.12) c19hcq.org Rojas-Serrano et al., PLOS ONE, May 2021 Favors HCQ Favors control

Hydroxychloroquine for prophylaxis of COVID-19 in health workers: A randomized clinical trial

Rojas-Serrano et al., PLOS ONE, doi:10.1371/journal.pone.0261980 (date from preprint), NCT04318015
May 2021  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now known with p < 0.00000000001 from 422 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,900+ studies for 60+ treatments. c19hcq.org
Early terminated HCQ PrEP RCT with 62 HCQ and 65 placebo patients, showing 82% lower cases with treatment, p = 0.12. If the trial is continued and the same event rate is observed, statistical significance will be reached after adding about 16 patients per arm.
risk of symptomatic case, 82.0% lower, RR 0.18, p = 0.12, treatment 1 of 62 (1.6%), control 6 of 65 (9.2%), NNT 13, adjusted per study.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Rojas-Serrano et al., 16 May 2021, Double Blind Randomized Controlled Trial, placebo-controlled, Mexico, peer-reviewed, median age 31.5, 8 authors, study period 14 April, 2020 - 31 March, 2021, trial NCT04318015 (history). Contact: jrojas@iner.gob.mx.
This PaperHCQAll
Hydroxychloroquine For Prophylaxis Of COVID-19 In Health Workers: A Randomized Clinical Trial
Jorge Rojas-Serrano, Angelica Margarita Portillo-Vásquez Thirion-Romero, Joel Vázquez-Pérez, Fidencio Mejía-Nepomuceno Alejandra Ramírez-Venegas, Karla Midori Pérez-Kawabe, Rogelio Pérez-Padilla
doi:10.1101/2021.05.14.21257059
Health care workers are at high risk of being infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). Our aim is to evaluate the efficacy and safety of hydroxychloroquine (HCQ) for prophylaxis of COVID19 in health personnel exposed to patients infected by SARS-COV-2. Methods: Double-blind randomized, placebo-controlled single center clinical trial. Included subjects were health care workers caring for severe COVD19 patients. Main outcome was time to symptomatic SARS-CoV2 infection. Results: 127 subjects with a confirmed baseline negative RT-PCR SARS-CoV2 test were included in the trial, 62 assigned to HCQ and 65 to placebo. One subject (1.6%) in the HCQ group and 6 (9,2%) subjects in the placebo group developed COVID-19. (Log Rank test p = 0.09). No severe COVID19 cases were observed. The study was suspended because of a refusal to participate and losses to follow up after several trials reported lack of effectiveness of hydroxychloroquine in hospitalized patients with COVID-19. CONCLUSION Although the number of symptomatic infections in health personnel was lower in the HCQ group, the difference was not statistically significant. The trial is underpowered due to the failure to complete the estimated sample size.
Hydroxychloroquine For Prophylaxis Of COVID-19 In Health SUMMARY Health care workers are at high risk of being infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). Our aim is to evaluate the efficacy and safety of hydroxychloroquine (HCQ) for prophylaxis of COVID19 in health personnel exposed to infected by SARS-COV-2. Methods: Double-blind randomized, placebo-controlled single center clinical trial. Included subjects were health care workers caring for severe COVD19 patients. Main outcome was time to symptomatic SARS-CoV2 infection. Results: 127 subjects with a confirmed baseline negative RT-PCR SARS-CoV2 test were included in the trial, 62 assigned to HCQ and 65 to placebo. One subject (1.6%) in the HCQ group and 6 (9,2%) subjects in the placebo group developed COVID-19. (Log Rank test p = 0.09). No severe COVID19 cases were observed. The study was suspended because of a refusal to participate and losses to follow up after several trials reported lack of effectiveness of hydroxychloroquine in hospitalized patients with COVID-19. CONCLUSION Although the number of symptomatic infections in health personnel was lower in the HCQ group, the difference was not statistically significant. The trial is underpowered due to the failure to complete the estimated sample size. Key words: COVID-19, health workers, prophylaxis, hydroxychloroquine,
References
Agren, Understanding Mexican Health Worker COVID-19 Deaths, doi:10.1016/S0140-6736(20)31955-3
Bandyopadhyay, Baticulon, Kadhum, Infection and mortality of healthcare workers worldwide from COVID-19: a systematic review, BMJ Glob Heal, doi:10.1136/bmjgh-2020-003097
Barranco, Ventura, Covid-19 and infection in health-care workers: An emerging problem, Med Leg J, doi:10.1177/0025817220923694
Booth, Bruno, Population risk factors for severe disease and mortality in COVID-19: A global systematic review and meta-analysis, Published, doi:10.1371/journal.pone.0247461
Colaneri, Novelli, Cutti, The experience of the health care workers of a severely hit SARS-CoV-2 referral Hospital in Italy: incidence, clinical course and modifiable risk factors for COVID-19 infection, J Public Health, doi:10.1093/pubmed/fdaa195
Doyno, Sobieraj, Baker, Toxicity of chloroquine and hydroxychloroquine following therapeutic use or overdose, Clin Toxicol, doi:10.1080/15563650.2020.1817479
Dy, Rabajante, A COVID-19 infection risk model for frontline health care workers, Netw Model Anal Heal Informatics Bioinforma, doi:10.1007/s13721-020-00258-3
Furst, Pharmacokinetics of hydroxychloroquine and chloroquine during treatment of rheumatic diseases, Lupus
Gies, Bekaddour, Dieudonné, Beyond Anti-viral Effects of Chloroquine/Hydroxychloroquine, Front Immunol, doi:10.3389/fimmu.2020.01409
Gohar, Larivière, Nowrouzi-Kia, Sickness absence in healthcare workers during the COVID-19 pandemic, Occup Med (Chic Ill), doi:10.1093/occmed/kqaa093
Horby, Mafham, Linsell, Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19, N Engl J Med, doi:10.1056/NEJMoa2022926
Id, Chaudhuri, Id, The efficacy and safety of hydroxychloroquine for COVID-19 prophylaxis: A systematic review and meta-analysis of randomized trials, Published, doi:10.1371/journal.pone.0244778
Indre, Para, Para, EL DIAGNÓSTICO DE SARS-CoV-2 DURANTE LA CONTINGENCIA DE COVID-19 EN MÉXICO, doi:10.2807/1560
Mehra, Desai, Ruschitzka, Patel, RETRACTED:Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis, Lancet. Published online, doi:10.1016/S0140-6736(20)31180-6
Mehta, Bhandari, Mehta, Why is pre-exposure prophylaxis with hydroxychloroquine a safe and rationale approach against SARS-CoV-2 infection?, J Glob Antimicrob Resist, doi:10.1016/j.jgar.2020.07.022
Nicol, Joshi, Rizk, Pharmacokinetics and Pharmacological Properties of Chloroquine and Hydroxychloroquine in the Context of COVID-19 Infection, Clin Pharmacol Ther. Published online, doi:10.1002/cpt.1993
Oliver, Gargano, Marin, The Advisory Committee on Immunization Practices' Interim Recommendation for Use of Pfizer-BioNTech COVID-19 Vaccine -United States, December 2020, MMWR Morb Mortal Wkly Rep, doi:10.15585/mmwr.mm6950e2
Peder, Id, Wiberg, A systematic review of trial registry entries for randomized clinical trials investigating COVID-19 medical prevention and treatment, Published, doi:10.1371/journal.pone.0237903
Rosenberg, Dufort, Udo, Association of Treatment with Hydroxychloroquine or Azithromycin with In-Hospital Mortality in Patients with COVID-19 in New York State, JAMA -J Am Med Assoc, doi:10.1001/jama.2020.8630
Schulz, Altman, Moher, Consort, Statement: Updated guidelines for reporting parallel group randomised trials, BMJ, doi:10.1136/bmj.c332
Singh, Ryan, Kredo, Chaplin, Fletcher, Chloroquine or hydroxychloroquine for prevention and treatment of COVID-19, Cochrane Database Syst Rev. Published online, doi:10.1002/14651858.cd013587.pub2
Wang, Zhou, Liu, Reasons for healthcare workers becoming infected with novel coronavirus disease 2019 (COVID-19) in China, J Hosp Infect, doi:10.1016/j.jhin.2020.03.002
Wei J Te, Liu, Fan, Zhao, Cao, Epidemiology of and risk factors for COVID-19 infection among health care workers: A multi-centre comparative study, Int J Environ Res Public Health, doi:10.3390/ijerph17197149
White, Watson, Hoglund, Chan, Cheah et al., COVID-19 prevention and treatment: A critical analysis of chloroquine and hydroxychloroquine clinical pharmacology, PLoS Med, doi:10.1371/journal.pmed.1003252
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