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0 0.5 1 1.5 2+ Mortality -35% Improvement Relative Risk Mortality (b) -8% c19hcq.com Rosenberg et al. HCQ for COVID-19 LATE TREATMENT Favors HCQ Favors control
Rosenberg, 1,483 patient HCQ late treatment study: 35% higher mortality [p=0.31] https://c19p.org/rosenberg
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Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State
Rosenberg et al., JAMA, May 11, 2020, doi:10.1001/jama.2020.8630
11 May 2020    Source   PDF   Share   Tweet
Restrospective observational late stage study showing no significant differences but calling for clinical trials.
Zervos et al. [ijidonline.com] point out serious limitations that they say should be corrected on the record: patients receiving HCQ with or without AZ were overall sicker on presentation and had multiple other risk factors including much higher risk based on ethnicity; patients receiving HCQ were more likely to be obese, diabetic, have chronic lung disease, and cardiovascular conditions; yet these sicker patients had approximately the same mortality rates compared to patients with a milder course of the disease and less risk factors. However, the authors conclude that "there are no significant benefits." It is noteworthy that HCQ was associated with a significant survival benefit in a larger cohort of patients from New York City as reported by [Mikami].
See also [worldtribune.com].
risk of death, 35.0% higher, HR 1.35, p = 0.31, treatment 189 of 735 (25.7%), control 28 of 221 (12.7%), adjusted per study.
risk of death, 8.0% higher, HR 1.08, p = 0.79, treatment 54 of 271 (19.9%), control 28 of 221 (12.7%), adjusted per study.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Rosenberg et al., 5/11/2020, retrospective, USA, North America, peer-reviewed, 14 authors.
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