203 hospitalized patients in France, not showing significant differences with treatment. Confounding by indication is likely. Authors do not discuss confounding.
Saib et al., 6/9/2021, prospective, propensity score matching, France, Europe, peer-reviewed, 9 authors.
risk of combined intubation/death, 125.0% higher, RR 2.25, p = 0.23, treatment 9 of 52 (17.3%), control 4 of 52 (7.7%), PSM.
This study is excluded in the after exclusion results of meta analysis: substantial unadjusted confounding by indication likely.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.