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0 0.5 1 1.5 2+ Median time to PCR- -21% Improvement Relative Risk c19hcq.com Saleemi et al. HCQ for COVID-19 LATE TREATMENT Favors HCQ Favors control
Saleemi, 85 patient HCQ late treatment study: 21% slower viral clearance [p=0.05] https://c19p.org/saleemi
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Time to negative PCR from symptom onset in COVID-19 patients on Hydroxychloroquine and Azithromycin - A real world experience
Saleemi et al., medRxiv, doi:10.1101/2020.08.05.20151027 (Preprint)
11 Aug 2020    Source   PDF   Share   Tweet
Retrospective 65 HCQ+AZ, 20 control patients, showing median time to negative PCR of 23 days for HCQ+AZ vs. 19 days for control. Confounding by indication. 100% of non-HCQ group had mild disease vs. 63% of the HCQ+AZ group. More comorbidities and symptoms in the HCQ+AZ group.
median time to PCR-, 21.0% higher, relative time 1.21, p < 0.05, treatment 65, control 20.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: substantial unadjusted confounding by indication likely.
Saleemi et al., 8/11/2020, retrospective, Saudi Arabia, Middle East, preprint, 5 authors.
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Late treatment
is less effective
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