Clinical Features and Prognostic Factors of 245 Portuguese Patients Hospitalized With COVID-19

Salvador et al., Cureus, doi:10.7759/cureus.13687 (Peer Reviewed)
Clinical Features and Prognostic Factors of 245 Portuguese Patients Hospitalized With COVID-19

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Prospective study of 245 hospitalized patients, 121 treated with HCQ, showing lower (non-statistically significant) mortality and higher ventilation at 30 days. Confounding by indication is likely.

Salvador et al., 3/4/2021, prospective, Portugal, Europe, peer-reviewed, 10 authors.

risk of death, 32.9% lower, RR 0.67, p = 0.007, treatment 28 of 121 (23.1%), control 58 of 124 (46.8%), odds ratio converted to relative risk, multivariate.

risk of mechanical ventilation, 447.8% higher, RR 5.48, p = 0.003, treatment 32 of 121 (26.4%), control 12 of 124 (9.7%), odds ratio converted to relative risk, multivariate.

risk of combined intubation/death, 16.7% lower, RR 0.83, p = 0.02, treatment 51 of 121 (42.1%), control 63 of 124 (50.8%), odds ratio converted to relative risk, univariate.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

All 320 studies Meta Analysis

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