Clinical Features and Prognostic Factors of 245 Portuguese Patients Hospitalized With COVID-19

3/4 Late treatment study

Salvador et al., Cureus, doi:10.7759/cureus.13687 (Peer Reviewed)
Clinical Features and Prognostic Factors of 245 Portuguese Patients Hospitalized With COVID-19

Source PDF Share Tweet

Prospective study of 245 hospitalized patients, 121 treated with HCQ, showing lower (non-statistically significant) mortality and higher ventilation at 30 days. Confounding by indication is likely.

Salvador et al., 3/4/2021, prospective, Portugal, Europe, peer-reviewed, 10 authors.

risk of death, 32.9% lower, RR 0.67, p = 0.007, treatment 28 of 121 (23.1%), control 58 of 124 (46.8%), odds ratio converted to relative risk, multivariate.

risk of mechanical ventilation, 447.8% higher, RR 5.48, p = 0.003, treatment 32 of 121 (26.4%), control 12 of 124 (9.7%), odds ratio converted to relative risk, multivariate.

risk of combined intubation/death, 16.7% lower, RR 0.83, p = 0.02, treatment 51 of 121 (42.1%), control 63 of 124 (50.8%), odds ratio converted to relative risk, univariate.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

All 344 studies Meta Analysis

Please send us corrections, updates, or comments. Vaccines and treatments are both extremely valuable and complementary. All practical, effective, and safe means should be used. Elimination of COVID-19 is a race against viral evolution. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. Denying the efficacy of any method increases the risk of COVID-19 becoming endemic; and increases mortality, morbidity, and collateral damage. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. Treatment protocols for physicians are available from the FLCCC.

Submit