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0 0.5 1 1.5 2+ Mortality 33% Improvement Relative Risk Ventilation -448% Death/intubation 17% c19hcq.com Salvador et al. HCQ for COVID-19 LATE TREATMENT Favors HCQ Favors control
Salvador, 245 patient HCQ late treatment study: 33% lower mortality [p=0.1], 448% higher ventilation [p=0.003], and 17% lower combined mortality/intubation [p=0.21] https://c19p.org/salvador
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Clinical Features and Prognostic Factors of 245 Portuguese Patients Hospitalized With COVID-19
Salvador et al., Cureus, doi:10.7759/cureus.13687
4 Mar 2021    Source   PDF   Share   Tweet
Prospective study of 245 hospitalized patients, 121 treated with HCQ, showing lower (non-statistically significant) mortality and higher ventilation at 30 days. Confounding by indication is likely.
risk of death, 32.9% lower, RR 0.67, p = 0.10, treatment 28 of 121 (23.1%), control 58 of 124 (46.8%), NNT 4.2, odds ratio converted to relative risk, multivariate.
risk of mechanical ventilation, 447.8% higher, RR 5.48, p = 0.003, treatment 32 of 121 (26.4%), control 12 of 124 (9.7%), odds ratio converted to relative risk, multivariate.
risk of death/intubation, 16.7% lower, RR 0.83, p = 0.21, treatment 51 of 121 (42.1%), control 63 of 124 (50.8%), NNT 12, odds ratio converted to relative risk, univariate.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Salvador et al., 3/4/2021, prospective, Portugal, Europe, peer-reviewed, 10 authors.
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