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0 0.5 1 1.5 2+ Case 6% Improvement Relative Risk c19hcq.com Salvarani et al. HCQ for COVID-19 PrEP Favors HCQ Favors control
Salvarani, HCQ prophylaxis study: 6% fewer cases [p=0.75] https://c19p.org/salvarani
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Susceptibility to COVID‐19 in Patients Treated With Antimalarials: A Population‐Based Study in Emilia‐Romagna, Northern Italy
Salvarani et al., Arthritis & Rheumatology, doi:10.1002/art.41475
6 Aug 2020    Source   PDF   Share   Tweet
Comparison of CQ/HCQ users with the general population in a region of Italy, showing no significant difference in the probability of COVID-19.
CQ/HCQ users were mostly systemic autoimmune disease patients and authors do not adjust for the very different baseline risk for these patients. Other research shows that the risk of COVID-19 for systemic autoimmune disease patients is much higher overall, Ferri et al. show OR 4.42, p<0.001 [Ferri].
risk of case, 6.0% lower, OR 0.94, p = 0.75, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: not fully adjusting for the different baseline risk of systemic autoimmune patients.
Salvarani et al., 8/6/2020, retrospective, population-based cohort, Italy, Europe, peer-reviewed, 18 authors.
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