Susceptibility to COVID‐19 in Patients Treated With Antimalarials: A Population‐Based Study in Emilia‐Romagna, Northern Italy

8/6 Pre-Exposure Prophylaxis study (treated before exposed to the virus)

Salvarani et al., Arthritis & Rheumatology, doi:10.1002/art.41475 (Peer Reviewed)
Susceptibility to COVID‐19 in Patients Treated With Antimalarials: A Population‐Based Study in Emilia‐Romagna, Northern Italy

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Comparison of CQ/HCQ users with the general population in a region of Italy, showing no significant difference in the probability of COVID-19.

CQ/HCQ users were mostly systemic autoimmune disease patients and authors do not adjust for the very different baseline risk for these patients. Other research shows that the risk of COVID-19 for systemic autoimmune disease patients is much higher overall, Ferri et al. show OR 4.42, p<0.001 [1].

Salvarani et al., 8/6/2020, retrospective, population-based cohort, Italy, Europe, peer-reviewed, 18 authors.

risk of COVID-19 case, 6.0% lower, RR 0.94, p = 0.75.

This study is excluded in meta analysis: not fully adjusting for the different baseline risk of systemic autoimmune patients.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

[1] c19study.com/ferri.html

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