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0 0.5 1 1.5 2+ Mortality 92% Improvement Relative Risk Mortality (b) 10% late Mortality (c) 51% late c19hcq.com Santos et al. HCQ for COVID-19 PrEP Favors HCQ Favors control
Santos, 38 patient HCQ prophylaxis study: 92% lower mortality [p=0.19] https://c19p.org/santos
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Determinants of COVID-19 disease severity in patients with underlying rheumatic disease
Santos et al., Clinical Rheumatology, doi:10.1007/s10067-020-05301-2
27 Jul 2020    Source   PDF   Share   Tweet
Prospective study of 38 hospitalized rheumatic disease patients with COVID-19 in Spain, showing no mortality with existing HCQ use compared to 32% without, not reaching statistical significance.
risk of death, 92.5% lower, RR 0.08, p = 0.19, treatment 0 of 7 (0.0%), control 10 of 31 (32.3%), NNT 3.1, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of death, 9.7% lower, RR 0.90, p = 1.00, treatment 8 of 31 (25.8%), control 2 of 7 (28.6%), NNT 36, HCQ, late treatment result.
risk of death, 50.8% lower, RR 0.49, p = 0.65, treatment 1 of 7 (14.3%), control 9 of 31 (29.0%), NNT 6.8, CQ, late treatment result.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
Santos et al., 27 Jul 2020, prospective, Spain, peer-reviewed, median age 78.4, mean age 75.3, 6 authors, study period 1 March, 2020 - 1 June, 2020.
Contact: cristysieirosantos@gmail.com.
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