Sbidian: Hydroxychloroquine with or without azithromycin and in-hospital mortality or discharge in patients hospitalized for COVID-19 infection: a cohort study of 4,642 in-patients in France

Sbidian, 4,642 patient HCQ late treatment study: 5% higher mortality [p=0.74] and 20% higher hospital discharge [p=0.002] https://c19p.org/sbidian

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Hydroxychloroquine with or without azithromycin and in-hospital mortality or discharge in patients hospitalized for COVID-19 infection: a cohort study of 4,642 in-patients in France

Sbidian et al., medRxiv, doi:10.1101/2020.06.16.20132597 (Preprint)

19 Jun 2020 Source PDF Share Tweet

Retrospective of 4,642 hospitalized patients in France showing significantly faster discharge with HCQ and HCQ+AZ. No significant effect is seen on 28-day mortality, however many more control patients are still in hospital at 28 days. Other studies show faster resolution for HCQ, suggesting there will be a significant improvement when extending past 28 days. Hopefully authors will extend the analysis. Note that the median age is higher in the group not treated with HCQ or AZ.

For other issues with the adjustments see [medrxiv.org]. Also see the analysis here [twitter.com].

1. medrxiv.org, https://www.medrxiv.org/content/10..020.06.16.20132597v1#disqus_thread.

2. twitter.com, https://twitter.com/Covid19Crusher/status/1274668697408471040.

risk of death, 5.0% higher, RR 1.05, p = 0.74, treatment 111 of 623 (17.8%), control 830 of 3,792 (21.9%), adjusted per study, whole population HCQ AIPTW adjusted.

risk of no hospital discharge, 20.0% lower, RR 0.80, p = 0.002, treatment 623, control 3,792, adjusted per study, whole population HCQ AIPTW adjusted.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

This study is excluded in the after exclusion results of meta analysis: significant issues found with adjustments.

Sbidian et al., 6/19/2020, retrospective, database analysis, France, Europe, preprint, 21 authors.

All Studies Meta Analysis

This Paper HCQ All

Late treatment
is less effective

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