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0 0.5 1 1.5 2+ ICU admission -133% Improvement Relative Risk Hospitalization -533% ICU admission (b) -142% Hospitalization (b) -142% c19hcq.com Schwartz et al. HCQ for COVID-19 RCT LATE TREATMENT Favors HCQ Favors control
Schwartz, 148 patient HCQ late treatment RCT: 133% higher ICU admission [p=1] and 533% higher hospitalization [p=0.57] https://c19p.org/schwartz2
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Assessing the efficacy and safety of hydroxychloroquine as outpatient treatment of COVID-19: a randomized controlled trial
Schwartz et al., CMAJ Open, doi:10.9778/cmajo.20210069
18 Jun 2021    Source   PDF   Share   Tweet
Small early terminated late treatment RCT not showing significant differences. The HCQ group was a median of 7 days from symptom onset at baseline, which may not include the delay delivering the medication. From the 4 HCQ hospitalizations, only one is in the per-protocol analysis, and that patient was hospitalized one day after randomization (authors do not specify if the patient received and took any HCQ before the hospitalization). The trial was terminated early due to the fraudulent Lancet article (wording here is notably different between the submitted and published versions). Per-protocol analysis, the submitted version, and the peer-review comments (two reviewers, only one with substantial feedback) are in the supplementary material.
risk of ICU admission, 133.3% higher, RR 2.33, p = 1.00, treatment 1 of 111 (0.9%), control 0 of 37 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).
risk of hospitalization, 533.3% higher, RR 6.33, p = 0.57, treatment 4 of 111 (3.6%), control 0 of 37 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).
risk of ICU admission, 141.9% higher, RR 2.42, p = 1.00, treatment 1 of 74 (1.4%), control 0 of 31 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), per-protocol.
risk of hospitalization, 141.9% higher, RR 2.42, p = 1.00, treatment 1 of 74 (1.4%), control 0 of 31 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), per-protocol.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Schwartz et al., 6/18/2021, Double Blind Randomized Controlled Trial, Canada, North America, peer-reviewed, 20 authors, average treatment delay 7.0 days, dosage 800mg day 1, 400mg days 2-5.
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