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0 0.5 1 1.5 2+ Symptomatic case 35% Improvement Relative Risk Case 32% c19hcq.com Seet et al. NCT04446104 HCQ RCT PEP Favors HCQ Favors vitamin C
Seet, 1,051 patient HCQ prophylaxis RCT: 35% fewer symptomatic cases [p=0.05] and 32% fewer cases [p=0.009] https://c19p.org/seeth
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Positive impact of oral hydroxychloroquine and povidone-iodine throat spray for COVID-19 prophylaxis: an open-label randomized trial
Seet et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.04.035
14 Apr 2021    Source   PDF   Share   Tweet
Prophylaxis RCT in Singapore with 3,037 low risk patients, showing lower serious cases, lower symptomatic cases, and lower confirmed cases of COVID-19 with all treatments (ivermectin, HCQ, PVP-I, and Zinc + vitamin C) compared to vitamin C.
Only 71.4% reported >70% adherence, limiting efficacy.
QTc did not statistically significantly differ between baseline and follow-up readings (mean 379 vs 378ms, paired t-test p=0.387).
Meta-analysis of vitamin C in 6 previous trials shows a benefit of 16%, so the actual benefit of ivermectin, HCQ, and PVP-I may be higher. Cluster RCT with 40 clusters.
There were no hospitalizations and no deaths. NCT04446104.
risk of symptomatic case, 35.1% lower, RR 0.65, p = 0.047, treatment 29 of 432 (6.7%), control 64 of 619 (10.3%), NNT 28.
risk of case, 32.0% lower, RR 0.68, p = 0.009, treatment 212 of 432 (49.1%), control 433 of 619 (70.0%), NNT 4.8, adjusted per study, odds ratio converted to relative risk, model 6.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Seet et al., 4/14/2021, Cluster Randomized Controlled Trial, Singapore, Asia, peer-reviewed, 15 authors, dosage 400mg day 1, 200mg days 2-42, this trial compares with another treatment - results may be better when compared to placebo, trial NCT04446104.
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