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0 0.5 1 1.5 2+ Symptomatic case 19% Improvement Relative Risk Case -6% Case (b) -22% c19hcq.com Shabani et al. HCQ for COVID-19 PEP Favors HCQ Favors control
Shabani, 113 patient HCQ prophylaxis study: 19% fewer symptomatic cases [p=1] and 6% more cases [p=1] https://c19p.org/shabani
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Evaluation of the Prophylactic Effect of Hydroxychloroquine on People in Close-Contact with Patients with Covid-19
Shabani et al., Pulmonary Pharmacology & Therapeutics, doi:10.1016/j.pupt.2021.102069
10 Aug 2021    Source   PDF   Share   Tweet
Small PEP trial with 51 HCQ patients, not showing a significant difference in cases. IRCT20130917014693N10.
risk of symptomatic case, 19.0% lower, RR 0.81, p = 1.00, treatment 2 of 51 (3.9%), control 3 of 62 (4.8%), NNT 109, day 7.
risk of case, 6.4% higher, RR 1.06, p = 1.00, treatment 7 of 51 (13.7%), control 8 of 62 (12.9%), day 7, PCR+ and symptomatic.
risk of case, 21.6% higher, RR 1.22, p = 0.78, treatment 7 of 51 (13.7%), control 7 of 62 (11.3%), day 7, PCR+ only.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Shabani et al., 8/10/2021, prospective, Iran, Middle East, peer-reviewed, 16 authors.
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